Many clinical applications have been found in the past for synthethic materials originally designed with
an alternative purpose in mind. Historically ‘off the shelf’ materials have been chosen for medical
applications due to their availability and seemingly appropriate mechanical properties.
The clinical community widely accepts the growing need for ‘bio-inspired’ materials that will be
mechanically compatible with the host tissue at the site of intended use.

Vysera has developed novel biomaterials that can mimic the mechanical properties of soft biological
tissues. Many existing biomaterials are either stiff engineering thermoplastics or thermoplastic
elastomers. Such conventional materials cannot approximate the complex mechanical behaviour of
dynamic anatomical systems. Various tissues, including those of the gastrointestinal system, stretch
readily but only relax back to their original dimensions gradually.

Vysera’s BioTx biomaterials are formed using proprietary chemistry, which facilitates the covalent
linking of disimilar biocompatible polymers. The resulting copolymers can be made to exhibit a variety
of properties, which thus enables the BioTx material to be ‘tailored’ to mechanically mimic the target
tissue of choice.

The patented chemistry used to link the polymer components together has been developed to
withstand the harsh environments within the human body. Stability testing of the materials in
simulated gastric juice has demonstrated a high level of ‘biostability’. This has enabled Vysera’s
development of medical devices for use in the GastroIntestinal tract.

The BioTx material has been incorporated into a reflux barrier, which functions as an asymmetric
valve. The valve, once fixed at the gastro esophageal junction, prevents the gastric contents from
refluxing into the esophagus. However the valve can be made to open from below with the force of
vomiting or belching. In the process of eating, the valve behaves very much like the native esophageal
tissue, expanding to accommodate the food bolus, which is propelled distally via normal peristalsis.